Funfest Productions, Inc. coordinates vending opportunities for small franchises, large corporations and local businesses. Our events give businesses the opportunity to reach a diverse audience. With anticipated combined attendance of 750,000+ patrons, this is a great opportunity to create additional revenue and enjoy free world-class entertainment and attractions. Contact us today for more information on food, merchandise, arts and craft vending!
We look forward to your call:
Kevin Cassidy, General Sales Manager
Kyle Gianotti, Food/Novelty Vendor Sales
Bone stem cells shown to regenerate bone and cartilage in adult mice
NEW YORK, NY (January 15, 2015) A stem cell capable of regenerating both bone and cartilage has been identified in bone marrow of mice. The discovery by researchers at Columbia University Medical Center (CUMC) is reported today in the online issue of the journal Cell.
The cells, called osteochondroreticular (OCR) stem cells, were discovered by tracking a protein expressed by the cells. Using this marker, the researchers found that OCR cells self renew and generate key bone and cartilage cells, including osteoblasts and chondrocytes. Researchers also showed that OCR stem cells, when transplanted to a fracture site, contribute to bone repair.
“We are now trying to figure out whether we can persuade these cells to specifically regenerate after injury. If you make a fracture in the mouse, these cells will come alive again, generate both bone and cartilage in the mouse and repair the fracture.
The researchers believe that OCR stem cells will be found in human bone tissue, as mice and humans have similar bone biology. Further study could provide greater understanding of how to prevent and treat osteoporosis, osteoarthritis, or bone fractures.
“Our findings raise the possibility that drugs or other therapies can be developed to stimulate the production of OCR stem cells and improve the body’s ability to repair bone injury a process that declines significantly in old age,” says Timothy C. Wang, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine at CUMC, who initiated this research. Previously, Dr. Wang found an analogous stem cell in the intestinal tract and observed that it was also abundant in the bone.
“These cells are particularly active during development, but they also increase in number in adulthood after bone injury,” says Gerard Karsenty, MD, PhD, the Paul A. Marks Professor of Genetics and Development, chair of the Department of Genetics Development, and a member of the research team.
The study also showed that the adult OCRs are distinct from mesenchymal stem wholesale cheap jerseys cells (MSCs), which play a role in bone generation during development and adulthood. Researchers presumed that MSCs were the origin of all bone, cartilage, and fat, but recent studies have shown that these cells do not generate young bone and cartilage. The CUMC study suggests that OCR stem cells actually fill this function and that both OCR stems cells and MSCs contribute to bone maintenance and repair in adults. Worthley (CUMC, University of Adelaide, SA, Australia, South Australian Health and Medical Research Institute, SA, Australia, and Royal Children’s Hospital, Vic., Australia), Michael Churchill (CUMC), Jocelyn T. Compton (CUMC), Yagnesh Tailor (CUMC), Meenakshi Rao (CUMC), Yiling Si (CUMC), Daniel Levin (Keck School of Medicine of the University of Southern California, CA), Matthew G. Schwartz (Harvard Medical School, Cambridge, MA), Aysu Uygur (Harvard), Yoku Hayakawa (CUMC), Stefanie Gross (CUMC), Bernhard W. Renz (CUMC), Wanda Setlik (CUMC), Ashley N. Martinez (CUMC), Xiaowei Chen (CUMC), Saqib Nizami (CUMC), Heon Goo Lee (CUMC), H. Paco Kang (CUMC, Jon Michael Caldwell (CUMC), Samuel Asfaha (CUMC), C. Benedikt Westphalen (CUMC and University Hospital Munich, Ludwig Maximilians University Munich Campus Gro Munich, Germany), Trevor Graham (Barts and the cheap jerseys free shipping London School of Medicine and Dentistry, Queen Mary University of London, London, UK), Guangchun Jin (CUMC), Karan Nagar (CUMC), Hongshan Wang (CUMC), Mazen A. Kheirbek ( CUMC), Alka Kolhe (CUMC), Jared Carpenter (CUMC), Mark Glaire (CUMC), Abhinav Nair (CUMC), Simon Renders (CUMC), Nicholas Manieri (Washington University in St Louis, MO), Sureshkumar Muthupalani (Massachusetts Institute of Technology, Cambridge, MA), James G. Fox (MIT), Maximilian Reichert (University of Pennsylvania Perelman School of Medicine, Philadelphia, PA), Andrew S. Giraud (CUMC), Robert F. Schwabe (CUMC)), Jean Phillipe Pradere (CUMC and Universit Paul Sabatier, Institut des Maladies M et Cardiovasculaires, Toulouse, France), Katherine Walton (University of Michigan, Ann Arbor, MI), Ajay Prakash (Michigan), Deborah Gumucio (Michigan), Anil K. Rustgi (Pennsylvania), Thaddeus S. Stappenbeck (Washington), Richard A. Friedman (CUMC)), Michael D. Gershon (CUMC), Peter Sims (CUMC), Tracy Grikscheit (Keck School of Medicine of the University of Southern California, Los Angeles, CA), and Francis Y. Lee (CUMC).
The study was funded by grants from the National Institutes of Health (5U54 CA126513, R01 RHL115145A, AR056246, and EB006834),), the Robert Carroll and Jane Chace Carroll Laboratories, the American Cancer Society, the NH and Menzies Foundation, Cancer Council SA’s Beat Cancer Project on behalf of its donors and the State Government of South Australia through the Department of Health, Gastroenterological Society of Australia, the American Gastroenterological Association, the American Association for Cancer Research, the Royal Australasian College of Physicians, and the Columbia University Ines Mandl Postdoctoral research fellowship.
Columbia University Medical Center provides international leadership in basic, preclinical, and clinical research; medical and health sciences education; and patient care. The medical center trains future leaders and includes the dedicated work of many physicians, scientists, public health professionals, dentists, and nurses at the College of Physicians and Surgeons, the Mailman wholesale jerseys School of Public Health, the College of Dental Medicine, the School of Nursing, the biomedical departments of the Graduate School of Arts and Sciences, and allied research centers and institutions. Columbia University Medical Center is home to the largest medical research enterprise in New York City and State and one of the largest faculty medical practices in the Northeast.
dedicated to the cure of cancer through innovative basic, clinical, physicians are dedicated to understanding the biology of cancer and tothat knowledge to the design of cancer therapies and prevention strategiesreduce its incidence and progression and improve the quality of cheap nba jerseys china the livesNCI designated comprehensive cancer centers in the United States, of which.Articles Connexes：
Articles cheap gucci bags about Sari ‘Lebaron Secret’ Airs Out Family Closets Of The Rich By Reviewed by Tee Roberts, Special to Christian Louboutin Online Store The Sentinel, February 23, 1986 In The LeBaron Secret, Stephen Birmingham takes another provocative look at the lifestyles of Replica Christian Louboutin Shoes the super rich. Like his best selling The Auerbach Will, this novel also centers on a will. When Peter LeBaron died, he left what he thought was a fair and equitable distribution of his wealth to his family his widow, Sari; his daughter and twin sons; his sister, Joanna, and her son. The family fortune derives from the Baronet Vineyards founded red bottoms by Peter’s grandfather in the Napa Valley and Sonoma. Sari Johnson, who was arrested Tuesday, was being held at the Marion County Jail, where she was denied bail. Investigators said that Johnson had been keeping her husband, who is legally blind and confined to a wheelchair, awake Replica Christian Louboutin at night by yelling at him and scolding him, and that she kept the temperature in their home at 60 degrees, against his wishes. They Christian Louboutin Replica also said Johnson had not
motor regulator replacement. Adding insult to injury, BMW of North cheap gucci handbags America has refused to make a "goodwill repair" because the car is "too old". Are you kidding me? A 6 year old car is too old to make a repair to an item that should have been recalled long ago for the cheaply made component failure? Simply said, my father, myself, and at least one other family member of mine has been a BMW customer for many years, and to say the least, they are all very disappointed in this. I will probably never buy another BMW after this experience, unless it’s made right, and I’m sure they’ll reconsider buying another one as well. It’s simply unacceptable to not stand behind your vibram five fingers shoes sale defective, expensive product when it fails this quickly out cheap gucci of warranty. The first 40,000 miles or so are just chi hair straightener dandy because everything that could go wrong is paid for under the factory warranty, but after that you’re on your own. Buyer beware: Unless you have money to burn on an already expensive car, I think I’d rather buy a Japanese